British Society for Matrix Biology

Monday 31st March

13.00 Welcome - Tony Day

13.05 Introductory Lecture - Iain Campbell (Department of Biochemistry, University of Oxford, UK)
Structure, assembly and binding of modular proteins

Session 1. Matrix remodelling

13.45 Dan Rifkin (Department of Cell Biology, New York School of Medicine, USA
Participation of matrix in the activation of latent TGF-beta: fact or fancy

14.15 Gill Murphy (Department of Oncology, University of Cambridge, UK)
Strategies for focussing TIMP function to the cell surface

14.45 Edward Bastow (Royal Veterinary College, London, UK).
Extracellular regulated kinase (ERK) activation augments HA-dependent pericellular matrix formation in embryonic chick articular surface cells

15.00 - 15.30 Tea, posters/trade exhibit

Session 2. Glycosaminoglycan structure/function - Sponsored by Seikagaku Corporation

15.30 John Sheehan (Department of Biochemistry and Biophysics, University of North Carolina, USA)
Structure and dynamics of hyaluronan

16.00 Barbara Mulloy (National Institute for Biological Standards and Control, UK)
Heparin-protein interactions in the extracellular matrix

16.30 Jeremy Turnbull (School of Biosciences, University of Birmingham, UK)
Heparan sulphates: structural diversity creates biological specificity

17.00-17.30 BSMB Annual General Meeting

17.30-19.15 Posters (with wine reception from 18.00)

19.15 Conference Dinner

 

Tuesday 1st April

Session 3. Fibrillar structures (part 1) - Sponsored by MicroCal

09.00 Dick Heinegård (Biomedical Centre, Lund University, Sweden)
Extracellular matrix as a complex assembly of molecules with a wide variety of functional domains

09.30 Jennifer Potts (Department of Biochemistry, University of Oxford, UK)
Binding of pathogenic bacteria to human fibronectin

10.00 Sian Hancock (School of Biosciences, Cardiff University, UK)
Type X collagen interacts with the small leucine rich proteoglycan decorin

10.15 Cay Kielty (School of Medicine, University of Manchester, UK)
Fibrillin microfibril assembly and function in extracellular matrices

10.45 - 11.15 Coffee

Session 4. Fibrillar structures (part 2)

11.15 Penny Handford (Department of Biochemistry, University of Oxford, UK)
Structure/function studies of the integrin-binding fragment from fibrillin-1

11.45 Catherine Moali (Institut de Biologie et Chimie des Protéines, Lyon, France)
Structure and specificity of procollagen C-proteinase enhancer 1

12.00 Raymond Boot-Handford (School of Biological Sciences, University of Manchester, UK)
Characterisation of a novel vertebrate fibrillar collagen (type XXVII collagen) with unusual 'invertebrate-like' molecular features

12.15 Erhard Hohenester (Department of Biological Sciences, Imperial College London, UK)
Insight into genetic diseases from structural analysis of matrix proteins

12.45-14.15 Lunch

13.30-14.15 Posters

Session 5. Matrix receptors

14.15 Martin Humphries (School of Biological Sciences, University of Manchester, UK)
The structural basis of integrin activation

14.45 Harri Altrof (Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK)
Structural requirements for the biological function of human fibronectin

15.00 Martin Stacey (Sir William Dunn School of Pathology, University of Oxford, UK)
Human myeloid cell-restricted EMR2 receptor mediates cell attachment through the binding of cell surface dermatan sulphate glycosaminoglycan

15.15 Christian Termeer (Department of Dermatology, University of Freiburg, Germany)
Oligosaccharides of hyaluronan activate dendritic cells via the toll-like receptor 4

15.30 David Stuart (The Wellcome Trust Centre for Human Genetics, University of Oxford, UK)
New structural approaches to integrins

16.00 Closing Remarks - Dick Heinegård

16.15 Tea /Close of meeting