British Society for Matrix Biology

Thursday, 18th September 2003

Registration from 08.00

Session 1. Extracellular Matrix and its Assembly

09.00 - 09.30 Jean Schwarzbauer (Princeton University, New Jersey, USA)
Function follows form: How fibronectin matrix architecture controls cell behaviour

09.30 - 10.00 Karl Kadler (University of Manchester, UK)
The ins then outs of extracellular matrix assembly

10.00 - 10.30 John Couchman (Imperial College, London, UK)
Basement membranes and tubular epithelial cell behaviour

10.30 - 11.00 Coffee and poster viewing

Session 2. Regulation of Matrix Synthesis

11.00 - 11.30 Andrew Chantry (University of East Anglia, Norwich, UK)
Smads proteins as positive and negative regulators of TGFb signalling

11.30 - 12.00 Nadia Wahab (Imperial College, London, UK)
The role of CTGF in fibrosis

12.00 - 12.30 Liliana Schaefer (Westfalische University, Münster, Germany)
Antifibrotic properties of decorin in renal disease - more than modulation of
TGFb activity

12.30 - 14.00 Lunch

Session 3. Inflammatory Regulation of Fibrosis

14.00 - 14.30 Josef Pfeilschifter (J.W. Goethe-Universität, Frankfurt, Germany)
Matrix-metabolizing enzymes as prime targets of redox regulation by nitric
oxide

14.30 - 15.00 Detlef Schlöndorff (University of Munich, Germany)
The role of chemokines in renal fibrosis

15.00 - 15.30 Jill Norman (University College, London, UK)
The role of hypoxia in fibrosis

15.30 - 16.00 Tea and poster viewing

Session 4. Transdifferentiation

16.00 - 16.30 Michael Ryan (University College Dublin, Ireland)
The molecular basis of fibrotic disease in the kidney

16.30 - 17.00 Frank Strutz (University of Göttingen, Germany)
Regulation of epithelial-mesenchymal transformation in vitro

17.00 - 17.30 Aled Phillips (University of Wales College of Medicine, Cardiff)
Regulation of renal proximal tubular cell phenotype and function

Evening Reception and Dinner

Friday, 19th September 2003

Session 5. Transgenics, Knock-outs and Fibrosis

09.00 - 09.30 BSMB committee meeting

09.30 - 10.00 Kathy Flanders (National Institutes of Health, Bethesda, MD, USA)
Smad3 as a mediator of the fibrotic response

10.00 - 10.30 Christos Chatziantoniou (Paris, France)
Mechanisms of progression and regression of renal fibrosis

10.30 - 11.00 Coffee and poster viewing

Session 6. Animal Models of Renal Disease

11.00 - 11.30 Charles Pusey (Imperial College, London, UK)
Regulation of inflammation and scarring in glomerulonephritis

11.30 - 12.00 Meguid El-Nahas (University of Sheffield, UK)
Renal fibrosis: lessons from experimental models

12.00 - 12.30 Kumar Sharma (Thomas Jefferson University, Philadelphia, PA, USA)
To be announced