13:30-14:00

Wilkins South Cloisters
Registration and coffee

14:00-15:15

Cruciform Lecture Theatre 1
Joint Symposium: New imaging technologies for cartilage and bone
Chairs: Miep Helfrich (Aberdeen, UK) & Michael Sherratt (Manchester, UK)

14:00

IS01
Using microCT to study bone architecture
Rob van’t Hof (Edinburgh, UK)

14:25

IS02
Imaging of osteochondral tissues
Alan Boyde (London, UK):

14:50

IS03
Towards understanding of osteoarthritis and joint health by contrast-enhanced MRI of cartilage
Leif Dahlberg (Malmö, Sweden):

15:15-15:50

Wilkins South Cloisters and Jeremy Bentham Room
Coffee

15:50-16:40

Cruciform Lecture Theatre 1
Joint Symposium: Life in an extreme environment
Chairs: Alan Boyde (London UK) & Tim Hardingham (Manchester, UK)

15:50

IS04
Earth (water), Wind (Oxygen) and Fire (Energy): A recipe for cell survival in a hostile environment
Irving Shapiro (Philadelphia, USA)

16:15

IS05
Osteocytes: birth, life and death in a mineralized tissue
Nigel Loveridge (Cambridge, UK)

16:50-17:50

Cruciform Lecture Theatre 1
New Investigator/Trainee Session
Chairs: Emma Blain (Cardiff, UK) & Nick Harvey (Southampton, UK)

John Williams (London, UK): Wellcome Trust Clinical/Basic Fellowship Schemes
Karl Kadler (Manchester, UK): MRC training fellowships/Fellowship versus lecturer routes in academia
Keith Thompson (Aberdeen, UK): ARC Fellow
Vicky MacRae (Edinburgh, UK): BBSRC Fellow and 2008 Barbara Mawer Visiting Fellowship recipient

19:00-20-15

‘Meet-the-Professor-in-the-Pub!’

This novel concept will enable you to discuss your research with key experts in an informal, convivial setting.

See information board next to registration desk for full details and locations. Please sign in for the session you would like to attend. Places are limited and will be allocated on a first-come first-served basis.

Charlie Archer & Bruce Caterson: Cartilage zonation

Jill Cornish & Chantal Chenu: Bone, brain and fat

Jim Gallagher & Alison Gartland: Nucleotides and bone

Tim Hardingham & Jerry Saklatvala: Can we fix articular cartilage?

Ken Poole & Nigel Loveridge: Sclerostin

Graham Riley & Roger Smith: Trouble with tendons

Tim Skerry & Brendon Noble: Bone responses to mechanical loading

David Abraham & Tim Cawston: Matrix repair

Basic Science Programme (in parallel with BRS Clinical Day)

09:00-09:15

Wilkins South Cloisters and Jeremy Bentham Room
Registration and coffee

09:00-09.15

Cruciform Lecture Theatre 1
Basic Science Symposium: New frontiers
Chairs: Bruce Caterson (Cardiff, UK) Peter Croucher (Sheffield, UK)

09:15

IS06
Micro RNAs and the skeleton
Ian Clark (Norwich, UK)

09:40

IS07
Zebrafish as a tool for skeletal biology
Henry Roehl (Sheffield, UK)

10:05

IS08
Ex-vivo and in-vivo gene delivery strategies using matrix pathology as a target
Yuti Chernajovsky (London, UK)

10:30-11:20

Wilkins South Cloisters and Jeremy Bentham Room
Coffee and commercial exhibition

11:20-12:10

Cruciform Lecture Theatre 1
Joint Symposium: The control of angiogenesis in bone and cartilage
Chairs: Jerry Saklatvala (London, UK) & Claire Clarkin (London, UK)

11:20

IS09
Vascularisation and bone remodeling
Marie-Hélène Lafage-Proust (St Etienne, France)

11:45

IS10
Targeting the HIF-1 pathway for bone repair
Tom Clemens (Birmingham, USA)

12:15-14:00

Wilkins South Cloisters and Jeremy Bentham Room
Lunch, commercial exhibition, posters

14:00-14:25

Cruciform Lecture Theatre 1
Joint Symposium: The control of angiogenesis in bone and cartilage (continued)

14:00

IS11
Molecular regulation of vascular calcification
Ann Canfield (Manchester, UK)

14:30-16:00

14:30




14:40





14:50





15:00





15:10





15:20




15:30




15:40

Cruciform Lecture Theatre 1
Joint Oral Communications (basic science)
Chairs: Colin Farquharson (Edinburgh, UK) & John Couchman (Copenhagen, Denmark)

OC1
Matrix mineralisation: A driver for osteocytogenesis?
M Prideaux, AA Pitsillides, C Farquharson
(Edinburgh, UK)

P031
The Wiskott-Aldrich syndrome protein verprolin homologous (WAVE) 1 is essential to localize MT1-MMP at the leading edge of migrating cells
BK Wolters, K Sato-Kusubata, N Ito, S Suetsugu, T Takenawa, Y Itoh
(London, UK)

OC2
Two populations of endochondral osteoblasts with differential sensitivity to Hedgehog signalling
CL Hammond, S Schulte-Merker
(Utrecht, The Netherlands)

P019
Chondroitin sulphation motifs identify putative chondroprogenitor cells in human osteoarthritic cartilage for use in ACT technologies.
S Mukhopadhyay, S Li, AJ Hayes, CE Hughes, MA Nowell, B Caterson
(Cardiff, UK)

OC3
Enhanced osteogeneisis of foetal and adult human bone marrow stromal cells cocultured with human umbilical vein endothelial cells
JM Kanczler, ROC Oreffo
(Southampton, UK)

P020
Fracture healing in GDF-5 deficient mice
CM Coleman, BH Scheremeta, A Boyce, RL Mauck, RS Tuan
(Galway City, Eire)

OC4
Phenotypic effects of hypoxia and hypoxia-inducible factor in Ewing’s sarcoma
HJ Knowles, L Schaefer, NA Athanasou
(Oxford, UK)

P033
CTGF plays a pivotal role in lung fibrosis through the MAPK dependent activation of collagen type I
M Ponticos, X Shi-wen, K Khan, P Leoni, GE Lindah, DJ Abraham
(London, UK)

15:50 -16:30

Wilkins South Cloisters and Jeremy Bentham Room
Tea and commercial exhibition

16:30-17:30

16:30








16:40







16:50





17:00







17:10








17:20

Cruciform Lecture Theatre 1
BRS Oral Communications (basic science)
Chairs: Jackie Berry (Manchester, UK) &
Kay Colston (London, UK)

OC5
Locally generated glucocorticoids, rather than pro-inflammatory cytokines, directly regulate synovial DKK-1 expression in inflammatory arthritis
RS Hardy, M Ahasan, P Patel, A Ahmed, A Filer, K Raza, CD Buckley, PM Stewart, MS Cooper
(Birmingham, UK)

OC6
Metabolomic studies identify true responders from non-responders to vitamin D supplementation in postmenopausal women
C Moniz, R Chandra, TJ Ong, C Meredith, C Mugglestone
(London, UK)

OC7
Osteocytes as you’ve never seen them before
GM Warnock, JS Gregory, KS Mackenzie, JG Greenhorn, AD McKinnon, MH Helfrich
(Aberdeen, UK)

OC8
APRIL, BAFF and NGF: Novel RANKL substitutes
F Jones, R Taylor, HJ Knowles, NA Athanasou
(Oxford, UK)




OC9
Novel use of digital image correlation to measure surface strains in loaded mouse tibiae discloses direct evidence of functional adaptation to limit peak strains
SJ Shefelbine, P Sztefek, M Vanleene 1, R Olsson, RC Collinson, AA Pitsillides
(London, UK)

OC10
Optimal bone mineralization and strength requires the type 2 iodothyronine deiodinase in osteoblasts
JHD Bassett, A Boyde, PGT Howell, RH Bassett, TM Galliford, M Archanco, DL St. Germain, VA Galton, GR Williams
(London, UK)

Cruciform Lecture Theatre 2
BSMB Oral Communications
Chairs: Graham Riley (Norwich, UK) &
Chris Watson (Manchester, UK)

P074
Molecular interactions of ADAMTS-4 in the VEGFR2 signalling complex
YP Hsu, CA Staton, DJ Buttle
(Sheffield, UK)

P086
Histone deacetylase inhibitors as chondroprotective agents
KL Culley, S Fenwick, IM Clark
(Norwich, UK)



P091
Mir-675 regulates collagen II levels in human articular chondrocytes
K Dudek, JE Lafont, CL Murphy
(London, UK)

P082
Knockout of P58IPK, a known inhibitor of PKR, in mice results in a degenerative phenotype in the knee joint
SJ Gilbert, M Patel, H Toumi, VC Duance, DJ Mason
(Cardiff, UK)

P081
Apoptosis in anteromedial gonarthrosis - evidence for the role of reactive oxygen species
R Rout, S Mcdonnell, S Snelling, X Dao, AJ Price, PA Hulley
(Oxford, UK)


P080
Imaging early molecular alterations in articular cartilage degeneration by Raman spectroscopy:diagnostic applications
J Dudhia, S Firth, PF McMillan, ERC Draper
(North Mymms, UK)

17:40-18:30

Cruciform Lecture Theatre 1
Joint Plenary Lectures
Chairs: Tim Arnett (London, UK) & Andy Pitsillides (London, UK)

17:40

BRS Dent Lecture: Denting the image of bone
Alan Boyde (London, UK)

18:05

BSMB Fell-Muir Lecture: Articular cartilage: the known and the unknown unknowns
Tim Hardingham (Manchester, UK)

18:30-20:30

Wilkins South Cloisters and Jeremy Bentham Room
Extended Reception and poster viewing

21:00

Recommended gastropubs

BRS Clinical Day (in parallel with Basic Science programme)

08:30-09:00        

Registration and coffee

09:00-09:25

Pearson Lecture Theatre
IS12
Advances in bone biology relevant to clinicians
Jon Tobias (Bristol, UK)

Chairs: Cyrus Cooper (Oxford and Southampton, UK) & Ken Poole (Cambridge, UK)

09:25-10:40       

Pearson Lecture Theatre
Bone Consults
Chairs: Juliet Compston (Cambridge, UK) & Sanjeev Patel (London, UK)

An opportunity to see how your clinical practice compares to academic clinical experts in the field

How should I use the FRAX tool in an osteoporosis clinic?
What do I do when a patient with OP treated with a bisphosphonate has a further fracture?
Should you ask for serum PTH when measuring serum 25OHD levels?
How do you use bone markers when treating patients with PTH?
When and how to treat an asymptomatic patient with Paget's disease of bone?
When do I refer a patient with an acute vertebral fracture for vertebroplasty?

Speakers to include:
Bill Fraser (Liverpool, UK)
Eugene McCloskey (Sheffield, UK)
Peter Selby (Manchester, UK)

10:40-11:20

Wilkins South Cloisters and Jeremy Bentham Room
Coffee and commercial exhibition

11:20-12:10

Cruciform Lecture Theatre 1
Joint Symposium: The control of angiogenesis in bone and cartilage

11:20

IS09
Vascularisation and bone remodeling
Marie-Hélène Lafage-Proust (St Etienne, France)

11:45

IS10
Targeting the HIF-1 pathway for bone repair
Tom Clemens (Birmingham, USA)

12:15-14:00

Wilkins South Cloisters and Jeremy Bentham Room
Lunch, commercial exhibition, posters

13:15-14:00

Posters - odd numbers

14:00

IS11
Molecular regulation of vascular calcification
Ann Canfield (Manchester, UK)

14:30

Pearson Lecture Theatre
IS13
Developmental mechanisms in the pathogenesis of osteoporosis 
Cyrus Cooper (Oxford and Southampton, UK)

Chairs: Eugeen McCloskey (Sheffield, UK) & Caje Moniz (London, UK)

14:50-15:50


14:50




15:05




15:20




15:35

Pearson Lecture Theatre
Clinical cases

CC1
Clinical and radiological features of Melorheostosis
M Chan, Y Zhang, P Wordsworth
(Oxford, UK)

CC2
Chronic hypomagnesaemia – a novel cause of tertiary hyperparathyroidism?
B Lopez, JH Tobias, Chris Probert, A Day
(Bristol, UK)

CC3
Bilateral atypical femoral stress fractures in patients receiving bisphosphonates
Thinn Hlaing, Juliet Compston
(Cambridge UK)

CC4
A case of male osteoporosis and indolent systemic mastocytosis
P Manghat, D Radia, M Moonim, C Grattan, G Hampson
(London, UK)

15:50-16:30   

Tea and commercial exhibition

Pearson Lecture Theatre
Satellite Symposium
The role of RANK ligand inhibition in osteoporosis and rheumatoid arthritis: Clinical trial update
Organised by Amgen

Chairs: Sanjeev Patel (London, UK) & Jon Tobias (Bristol, UK)

Treatment of postmenopausal bone loss with RANKL inhibition; the STAND and DECIDE study
Juliet Compston (Cambridge, UK)

Rank ligand Inhibition: Phase 2 data in rheumatoid arthritis
David Reid (Aberdeen, UK)

17:40-18:30

Cruciform Lecture Theatre 1
Joint Plenary Lectures
Chairs: Tim Arnett (London, UK) & Andy Pitsillides (London, UK)

17:40

BRS Dent Lecture: Denting the image of bone
Alan Boyde (London, UK)

18:05

BSMB Fell-Muir Lecture: Articular Cartilage: the Known and the Unknown Unknowns
Tim Hardingham (Manchester, UK)

18:30-20:30

Wilkins South Cloisters and Jeremy Bentham Room
Extended reception and poster viewing

08:00-08:30

Coffee / croissants / fruit

08:30-09:45

Cruciform Lecture Theatre 1
Joint Symposium:  Skeletal development
Chairs: Irving Shapiro (Philadelphia, USA) & Charlie Archer (Cardiff, UK)

08:30

IS14
Molecular mechanisms of skeletal morphogenesis
Bjorn Olsen (Boston, USA)

08:55

IS15
Bone development and dysplasias
Stefan Mundlos (Berlin, Germany)

09:20

IS16
Osteoblast differentiation is regulated by multiple signalling pathways in the zebrafish embryo
Henry Roehl (Sheffield, UK)

09:45-10:30

Wilkins South Cloisters and Jeremy Bentham Room
Coffee and commercial exhibition

10:30-11:50

Cruciform Lecture Theatre 1
BRS Oral Communications
Chairs: Marie-Hélène Lafage-Proust (St. Etienne, France) & Nick Harvey (Southampton, UK)

OC11
Gender differences in hip structure in peripubertal children
A Sayers, JH Tobias
(Bristol, UK)




OC12
A pilot trial of the effects of vitamin D2 supplementation upon bone in post-pubertal girls
KA Ward, G Das, SA Roberts, JL Berry, JE Adams, MZ Mughal
(Cambridge, UK)

OC13
Abnormalities in the distribution of sclerostin positive and negative osteocytes in the cortical osteon in a hip fracture model of osteoporosis
J Reeve, J Power, M Doube, R van Bezooijen, KES Poole, N Loveridge
(Cambridge, UK)

OC14
Relationship between different domains of physical activity and fractures: Results from the EPIC-Norfolk study
A Moayyeri, R Luben, S Bingham, N Wareham, KT Khaw
(Cambridge, UK)

OC15
Effect of intermittent hPTH (1-34) on 1,25 (OH)2 vitamin D, bone formation and Fibroblast Growth Factor-23 (FGF-23) in post-menopausal osteoporosis
M Sridharan, P Manghat, I Fogelman, WD Fraser, G Hampson
(London, UK)

OC16
Inactivating mutations in RANK result in diseases with opposite phenotypes
DJ Mellis, A Duthie, M Guerrini, A Villa, MH Helfrich, MJ Rogers, JC Crockett
(Aberdeen, UK)

OC17
Inhibiting glycogen synthase kinase-3 (GSK-3) prevents the development of myeloma bone disease
NG Abdul, W Stoop, W Koopman, M Djerbi, AD Chantry, H Evans, K Vanderkerken, PI Croucher
(Sheffield, UK)

OC18
Blockade of the ALK1 receptor reduces tumour microvessel density and prevents the development of osteolytic bone disease in the 5T2MM murine model of myeloma
AD Chantry, L Coulton, O Gallagher, H Evans, J Seehra, S Pearsall, H De Raeve, K Vanderkerken, PI Croucher
(Sheffield, UK)

Cruciform Lecture Theatre 2
BSMB Open Session
Chairs: Tonia Vincent (London, UK) &
Bjorn Olsen (Boston, USA)


P064
FGF receptor-dependent, integrin-independent phosphorylation of p38, JNK and ERK MAPKs following mechanical stimulation of human articular chondrocytes in primary monolayer cell culture
Y Zhou, C Beadle, DM Salter, G Nuki
(Edinburgh, UK)

P034
Structural and regulatory components of the pericellular matrix of young and mature articular cartilage
C McLean, J Saklatvala, T Vincent
(London, UK)


P021
Expansion on a hyaluronan coated surface enhances the chondrogenic potential of human mesenchymal stem cells
C Ryan, C Coleman, M Murphy, F Barry
(Galway, Eire)


P066
Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury
N Eltawil, C Pitzalis, F Dell'Accio
(London, UK)


P088
Involvement of NMDAR in chondrocyte cell death and matrix degeneration
L Ramage, GE Hardingham, DM Salter
(Edinburgh, UK)




P022
Clonal mesenchymal stem cell populations derived from the synovial fat pad exhibit a similar cell surface characterisation profile but variable osteogenic and chondrogenic differentiation potential
WS Khan, SR Tew, A Adesida, JG Andrew, TE Hardingham
(Manchester, UK)

P060
Mechanical strain modulation of Matrix Metalloproteinases in human tenocytes
ER Jones, GC Jones, GP Riley
(Norwich, UK)



P065
Mechanical loading of murine knee joints: determining the interplay between genetics and mechanical loading in the development of OA
B Poulet, AA Pitsillides
(London, UK)

11:50

Break

Cruciform Lecture Theatre 1
BRS - Cancer and bone
Chairs: Tim Chambers (London, UK) &
Tom Clemens (Alabama, USA)

Cruciform Lecture Theatre 2
BSMB - Matricellular proteins in health and disease
Chairs: David Abraham (London, UK) &
Hideaki Nagase (London, UK)

12:00

IS17
Cancer in bone: an overview
Nick Athanasou (Oxford, UK)

IS19
The roles of connective tissue growth factor and CYR61 in skeletal development
Karen Lyons (Los Angeles, USA)

12:25

IS18
Interactions between cancer cells and bone cells: unresolved issues
Peter Croucher (Sheffield, UK)

IS20
Roles of matrilins and COMP in cartilage matrix assembly and in the pathogenesis of chondrodysplasias
Mats Paulsson (Cologne, Germany)

12:50-14:20

Wilkins South Cloisters and Jeremy Bentham Room
Lunch and commercial exhibition

13:15-14:00

Wilkins South Cloisters and Jeremy Bentham Room
Posters - even numbers

13:45

AGMs (concurrent)

BRS - Cruciform Lecture Theatre 1

BSMB - Cruciform Lecture Theatre 2

14:20-15:20



14:20





14:25





14:30




14:35





14:40





14:45




14:50





14:55





15:00




15:05





15:10





15:15

Cruciform Lecture Theatre 1
Joint Oral Posters
Chairs: Ray Boot-Handford (Manchester, UK) & Nigel Loveridge (Cambridge, UK)

P098
The elastic network in human articular cartilage: an immunohistochemical study of elastin fibres and microfibrils
J Yu, S Roberts, EH Evans, JP Urban
(Oxford, UK)

P071
eNOS null osteoblasts produce Nitric Oxide in response to fluid flow but do not translocate β-catenin
C Huesa, RM Aspden, MH Helfrich
(Aberdeen, UK)

P076
Anti-angiogenic properties of proteoglycan in cartilage explant cultures
JJ Bara, S Roberts, WEB Johnson
(Oswestry, UK)

P130
Increased fat mass and reduced serum osteocalcin in individuals with high bone mass: possible cross-talk between fat and bone metabolism
CL Gregson, S Steel, WD Fraser, JH Tobias
(Bristol, UK)

P023
Evaluation of bone marrow mesenchymal stem cell therapy for tendon regeneration in a large animal model
NJ Young, J Dudhia, AE Goodship, RK Smith
(North Mymms, UK)

P053
Calcium-induced secretion of DKK-1 in osteoblastic cells
HS McCarthy, JH Williams, MWJ Davie, MJ Marshall
(Gobowen, UK)

P029
The PPARα agonist rosiglitazone reverses the persistent fibrotic phenotype of scleroderma fibroblasts
X Shi-wen, M Eastwood, CP Denton, A Leask, DJ Abraham
(London, UK)

P008
The inhibitory role of suppressor of cytokine signalling-2 on STAT signalling in the growth plate
C Pass, VE MacRae, SF Ahmed, C Farquharson
(Edinburgh, UK)

P061
Lovastatin upregulates chondrocyte marker expression in tenocytes
HR Cornell, AJ Carr, PA Hulley
(Oxford, UK)

P055
Mild hypothermia promotes osteoclastogenesis whilst retarding osteoblast differentiation and bone formation
JJ Patel, IR Orriss, ML Key, SEB Taylor, K Karnik, TR Arnett
(London, UK)

P079
In Situ ultrastructural imaging of native extracellular matrix macro-molecules
HK Graham, CEM Griffiths, NW Hodson, JA Hoyland, J Millward-Sadler, AW Trafford, REB Watson, MJ Sherratt
(Manchester, UK)

P041
A role for TRPV1 and K+ channels in the regulation of osteoblast transdifferentiation to adipocytes
NC Henney, A Thomas, BAJ Evans, KT Wann
(Cardiff, UK)

15:20-15:45

Wilkins South Cloisters and Jeremy Bentham Room
Tea

15:45

IS21
Intrinsic matrix properties direct stem cell fate: insights into anomalous bone formation
Adam Engler (San Diego, USA)

16:10

IS22
Fibrous dysplasia - models of disease, models of therapy
Paolo Bianco (Rome, Italy)

16:35

IS23
ER (endoplasmic reticulum) stress as a pathogenic factor in chondrodysplasia 
Ray Boot-Handford (Manchester, UK)

17:00-17:15

Cruciform Lecture Theatre 1
Awards
Chairs: Bruce Caterson (Cardiff, UK) & Jon Tobias (Bristol, UK)

17:15

Close